July 9, 2008Journal of Cardiovascular Electrophysiology
Mortality of Heart Failure Patients After Cardiac Resynchronization Therapy: Identification of Predictors
Key result
In patients with congestive heart failure, CRT-D was associated with significantly lower all-cause mortality compared to CRT-P (18.5% vs. 38.8%; OR 0.334, P=0.003).
Why the study?
Does CRT-D reduce all-cause mortality compared to CRT-P in patients with congestive heart failure?
Population
542 consecutive patients with congestive heart failure (CHF) indicated for biventricular pacing
Comparison
Cardiac resynchronization therapy-defibrillator vs Cardiac resynchronization therapy-pacemaker
Design
Cohort, None (nonrandomized)
Authors
Discussion
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Implication
CRT-D was associated with lower mortality than CRT-P in this registry; hypothesis-generating and should not yet change device selection in heart failure.
Study Design
Type
Cohort (n=542)
Structured PICO
Does CRT-D reduce all-cause mortality compared to CRT-P in patients with congestive heart failure?
P
Population
542 consecutive patients with congestive heart failure implanted with either CRT-P or CRT-D between 1999 and 2005.
E
Exposure
Cardiac resynchronization therapy-defibrillator (CRT-D)
C
Comparator
Cardiac resynchronization therapy-pacemaker (CRT-P)
O
Outcome
All-cause mortality during follow-uphard clinical
Main Result
Odds Ratio: 0.334
Absolute Event Rate: 18.5% vs 38.8%
p-value: p=0.003
In a nonrandomized registry of heart failure patients, CRT-D was associated with significantly lower all-cause mortality compared to CRT-P.
Limitations
- Nonrandomized study design
Cite This Study
Bai et al. (2008) conducted a cohort in Congestive heart failure (n=542). CRT-D vs. CRT-P was evaluated on All-cause mortality (OR 0.334, p=0.003). In patients with congestive heart failure, CRT-D was associated with significantly lower all-cause mortality compared to CRT-P (18.5% vs. 38.8%; OR 0.334, P=0.003).