Levi Levilactobacillus brevis (TCI988) Supplementation Enhances Sleep Quality

Levilactobacillus brevis (TCI988) is a probiotic known for improving gut health, enhancing the immune system, and reducing inflammation and improved sleep quality.The aim of this study was to investigate whether L. brevis increased deep sleep and improve stress.Neuro-2a cells were treated with TCI988 for 24 hours, and then examined mitochondrial activity and related melatonin genes.In addition, subjects analyzed the GABA concentration and sleep and stress status.TCI988 can increase neuronal cell mitochondrial activity by 33.4% compared to the mock, and increased the expression of SIRTs, TPH1, and DDC by about 1.3, 1.23, and 1.05-fold, respectively, compared to the mock.The serum GABA level of the subjects increased from 125.0 ng/mL to 199.1 ng/mL after consuming TCI988 for 4 weeks, and increased deep sleep time and improved stress.L. brevis showed promise as a natural remedy for improving sleep quality.