Key result
Spinal anesthesia and adjuvant spinal anesthesia reduced systolic and diastolic blood pressure by 23-28% compared to multimodal general anesthesia, resulting in a 33-fold lower risk of hypertension (OR 33.0).
Why the study?
Does spinal anesthesia (with or without adjuvants) improve hemodynamic stability compared to multimodal low-opioid general anesthesia in women undergoing abdominal hysterectomy?
Population
118 women aged 35-65 years undergoing abdominal hysterectomy
Comparison
Multimodal low-opioid general anesthesia vs spinal anesthesia vs adjuvant spinal anesthesia
Design
Comparative study
Follow-up
6 hours postoperatively
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Supports spinal anesthesia for hemodynamic stability in abdominal hysterectomy; extends RCT evidence favoring regional over multimodal general anesthesia.
RCT (n=118)
Randomly divided
No
Does spinal anesthesia (with or without adjuvants) improve hemodynamic stability compared to multimodal low-opioid general anesthesia in women undergoing abdominal hysterectomy?
Odds Ratio: 33
Absolute Event Rate: 0% vs 31.9%
Absolute Risk Reduction: 31.9%
p-value: p=<0.001
Spinal anesthesia, particularly with adjuvants, provides more stable hemodynamics and a significantly lower risk of hypertension compared to multimodal general anesthesia during abdominal hysterectomy, though adjuvant use increases the risk of bradycardia.
A 2025 study conducted an RCT in Abdominal hysterectomy (n=118). Spinal anesthesia (with or without adjuvants) vs. Multimodal low-opioid general anesthesia was evaluated on Risk of hypertension (SBP > 150 mmHg) (OR 33.0, p=<0.001). Spinal anesthesia and adjuvant spinal anesthesia reduced systolic and diastolic blood pressure by 23-28% compared to multimodal general anesthesia, resulting in a 33-fold lower risk of hypertension (OR 33.0).
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