Key result
Initiation of the synthetic progestin dydrogesterone was associated with the development of Takotsubo cardiomyopathy in a 40-year-old premenopausal woman.
Why the study?
Because Takotsubo cardiomyopathy predominantly affects postmenopausal women, female sex hormones have been postulated to play a role in its pathogenesis.
Case Report (n=1)
No
This case report describes the first instance of Takotsubo cardiomyopathy associated with the initiation of dydrogesterone in a premenopausal woman.
Should not change practice; single case leaves open possible dydrogesterone-Takotsubo link requiring confirmation.
Takotsubo cardiomyopathy is characterised by left ventricular apical ballooning, in the absence of coronary artery disease, and classically occurs at times of intense stress. Due to the striking preponderance of Takotsubo cardiomyopathy occurring in postmenopausal women, it has been postulated that female sex hormones may also be implicated in its pathogenesis. This case report describes the first case of Takotsubo cardiomyopathy associated with the initiation of dydrogesterone (a synthetic retroprogesterone) in a premenopausal woman.
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Adam Ioannou (2021) conducted a case report in Takotsubo cardiomyopathy (n=1). Dydrogesterone was evaluated on Development of Takotsubo cardiomyopathy. Initiation of the synthetic progestin dydrogesterone was associated with the development of Takotsubo cardiomyopathy in a 40-year-old premenopausal woman.
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