Key result
Massive sympathetic nervous system activation in rabbits reduced myocardial high-energy phosphate compounds, though ischemia did not appear to be the underlying mechanism.
Why the study?
Does massive sympathetic nervous system activation alter coronary blood flow and myocardial energy pool in anesthetized rabbits?
Does massive sympathetic nervous system activation alter coronary blood flow and myocardial energy pool in anesthetized rabbits?
Massive sympathetic nervous system activation causes a transient fall in myocardial high-energy phosphates, but ischemia does not appear to be the underlying mechanism for the resulting LV dysfunction.
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Rabbit model implicates ischemia in SNS-induced LV dysfunction; leaves open human translation.
Smith et al. (2002) studied Massive sympathetic nervous system activation. Intracisternal injection of veratrine vs. Baseline (time 0) was evaluated on Coronary blood flow and myocardial ATP, creatine phosphate, and lactate concentrations. Massive sympathetic nervous system activation in rabbits reduced myocardial high-energy phosphate compounds, though ischemia did not appear to be the underlying mechanism.
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