What question did this study set out to answer?

To review the mechanisms, diagnostic criteria, therapeutic strategies, and long-term clinical outcomes associated with antibody-mediated rejection (AMR) in lung transplantation.

March 1, 2020Annals of Translational MedicineOpen Access

Antibody-mediated rejection after lung transplantation

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Authors

ABAmit BeryWashington University in St. Louis RHRamsey R. HachemWashington University in St. Louis

Discussion

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Implication

Review reveals poor survival and diagnostic limits for antibody-mediated rejection in lung transplant recipients, indicating a need for standardized treatment trials.

Key Points

To review the mechanisms, diagnostic criteria, therapeutic strategies, and long-term clinical outcomes associated with antibody-mediated rejection (AMR) in lung transplantation.
Narrative synthesis of clinical and translational literature evaluating acute and chronic forms of AMR after lung transplantation.
Analysis of the international consensus diagnostic criteria and off-label therapeutic modalities repurposed from other solid organ transplants.
AMR is frequently refractory to empirical treatments, resulting in high rates of graft failure and mortality.
The condition strongly correlates with increased incidence of chronic lung allograft dysfunction and compromised long-term recipient survival.
Current consensus diagnostic criteria possess notable limitations, underscoring the need for head-to-head clinical trials and refined definitions for subclinical and chronic rejection.

Cite This Study

Bery et al. (2020) studied this question.

synapsesocial.com/papers/6a6cb1d426a7f98052db4a86 https://doi.org/10.21037/atm.2019.11.86

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Implication

Review reveals poor survival and diagnostic limits for antibody-mediated rejection in lung transplant recipients, indicating a need for standardized treatment trials.

Antibody-mediated rejection after lung transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

Antibody-mediated rejection after lung transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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