Key result
In vivo exposure of up to 108 months did not significantly degrade the load to failure (p=0.82), ultimate tensile strength (p=0.82), or modulus of elasticity (p=0.12) of left ventricle leads.
Why the study?
Left ventricle leads are designed for long-term pacing, and this study investigated the mechanical behavior and residual properties of leads using polyurethane outer insulation and SI-polyimide inner insulation after in vivo exposure.
Population
Ten explanted left ventricle leads using polyurethane outer insulation and SI-polyimide inner insulation
Comparison
Mechanical properties across varying in vivo implantation durations (less than a month to 108 months)
Design
Ex vivo mechanical testing study
Authors
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Supports LV lead durability in long-term animal exposure; leaves open human translation and clinical outcomes.
p-value: p=0.82, 0.62, 0.82, 0.12
The residual mechanical properties of polyurethane-insulated left ventricle leads remain relatively stable after up to 108 months of in vivo exposure, with no statistically significant degradation in load to failure or ultimate tensile strength.
Salih et al. (2024) studied Cardiac implantable electronic devices (n=10). In vivo exposure was evaluated on Load to failure, percentage of elongation to failure, ultimate tensile strength, and modulus of elasticity (p=0.82, 0.62, 0.82, 0.12). In vivo exposure of up to 108 months did not significantly degrade the load to failure (p=0.82), ultimate tensile strength (p=0.82), or modulus of elasticity (p=0.12) of left ventricle leads.
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