Key result
Fifteen weeks of high-fat diet in mice induced obesity-related diastolic dysfunction and reduced global longitudinal strain (-15.1% vs -20.0%), accompanied by lower mean diffusivity in the left-ventricular base.
Why the study?
Obesity causes multiple deleterious effects on the heart that may lead to cardiac failure, prompting characterization of myocardial microstructure and function in an experimental model of obesity-related cardiac dysfunction.
Does a high-fat diet induce alterations in myocardial microstructure and function in a murine model?
Comparison
High-fat diet (60 kcal% fat, n = 12) vs standard control diet (9 kcal% fat, n = 10)
Design
Animal experimental study
Follow-up
15 weeks
Authors
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Characterizes myocardial changes in obese mice; leaves open translation to human obesity-related cardiomyopathy.
Does a high-fat diet induce alterations in myocardial microstructure and function in a murine model?
Absolute Event Rate: -15.1% vs -20%
p-value: p=0.01
Diet-induced obesity in mice leads to diastolic dysfunction and regional alterations in myocardial diffusion properties before the onset of fibrosis or three-dimensional myofiber remodeling.
Lohr et al. (2022) studied Obesity-related cardiac dysfunction (n=21). High-fat diet vs. Standard control diet (9 kcal% fat) was evaluated on Global longitudinal strain (p=0.01). Fifteen weeks of high-fat diet in mice induced obesity-related diastolic dysfunction and reduced global longitudinal strain (-15.1% vs -20.0%), accompanied by lower mean diffusivity in the left-ventricular base.
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