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January 1, 2016Journal of Cardiovascular Magnetic ResonanceOpen Access

Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet

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Why the study?

Does a high-fat diet reduce myocardial perfusion reserve and increase left-ventricular mass in C57Bl/6 mice?

Population

20 male C57Bl/6 mice (n=11 high-fat diet, n=9 control), starting at 6 weeks of age.

Comparison

High-fat diet for up to 24-26 weeks. vs Low-fat diet for up to 24-26 weeks.

Design

Preclinical

Follow-up

24-26 weeks

Authors

NNNivedita K. NareshJBJoshua T. ButcherRLR. John Lye

Discussion

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Overview

Supports high-fat diet C57Bl/6 mice as a model of obesity-related impaired MPR; leaves open translation to human CMD.

Structured PICO

Does a high-fat diet reduce myocardial perfusion reserve and increase left-ventricular mass in C57Bl/6 mice?

P
Population
20 male C57Bl/6 mice (n=11 high-fat diet, n=9 control), starting at 6 weeks of age.
I
Intervention
High-fat diet (60% calories from fat) for up to 24-26 weeks.
C
Comparator
Low-fat diet (10% calories from fat) for up to 24-26 weeks.
O
Outcome
Myocardial perfusion reserve (MPR), left-ventricular (LV) mass, and LV wall thickness assessed by cardiovascular magnetic resonance at 6, 12, 18, and 24 weeks post-diet.surrogate

C57Bl/6 mice fed a high-fat diet for 18-24 weeks develop progressively increased LV mass and impaired myocardial perfusion reserve with fibrosis, establishing them as a model for impaired MPR without obstructive CAD due to obesity and diabetes.

Cite This Study

Naresh et al. (2016) studied this question.

synapsesocial.com/papers/6a7f72d1024876978df6d9d5https://doi.org/10.1186/s12968-016-0273-y
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Also Consider

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