Key result
Higher dietary protein intake increased glomerular AngII binding in normotensive rats but reduced it in virgin spontaneously hypertensive rats, without affecting blood pressure.
Why the study?
Does varying dietary protein intake affect glomerular binding of angiotensin II in normotensive and spontaneously hypertensive rats?
Does varying dietary protein intake affect glomerular binding of angiotensin II in normotensive and spontaneously hypertensive rats?
Protein-induced changes in glomerular AngII binding do not explain the known increase in glomerular plasma flow and filtration rate in response to increased protein intake.
Dietary protein modulation of glomerular AngII binding in rat models of hypertensive pregnancy leaves open any human relevance; prospective clinical studies needed.
The effect of varying dietary protein intake from 16% to 35% (w/w) on glomerular binding of angiotensin II (AngII) has been studied in virgin and pregnant normotensive and spontaneously hypertensive rats. Although the higher protein diet caused an increase in AngII binding by glomeruli from both virgin and pregnant nomotensive rats a reduction was noted in virgin spontaneously hypertensive rats. These changes in binding were unassociated with any change in the binding affinity constant and unrelated to changes in blood pressure or plasma renin activity in any of the groups of rats studied. The protein-induced changes in glomerular AngII binding cannot explain the increase in glomerular plasma flow and glomerular filtration rate known to occur in response to an increase in protein intake.
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Barbour et al. (1993) studied Normotension and spontaneous hypertension in rats. Higher dietary protein intake vs. 16% (w/w) dietary protein intake was evaluated on Glomerular binding of angiotensin II (AngII). Higher dietary protein intake increased glomerular AngII binding in normotensive rats but reduced it in virgin spontaneously hypertensive rats, without affecting blood pressure.
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