Key result
Higher levels of physical exercise were associated with significantly longer T1-relaxation times in knee cartilage (382 ms in nonexercisers vs 424 ms in moderate exercisers vs 476 ms in elite runners).
Why the study?
Does physical exercise increase glycosaminoglycan content in human knee cartilage as measured by dGEMRIC?
Population
37 age-matched healthy volunteers with different levels of physical activity
Comparison
Physical exercise (twice weekly or elite running) vs Nonexercising individuals
Design
Cross-sectional
Authors
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Higher activity linked to greater knee cartilage GAG content; leaves open causal adaptation versus selection effects in observational data.
Cross-Sectional (n=37)
Does physical exercise increase glycosaminoglycan content in human knee cartilage as measured by dGEMRIC?
Absolute Event Rate: 476% vs 382%
p-value: p=0.0004 (Group 1 vs 2); 0.0002 (Group 2 vs 3)
Human knee cartilage adapts to physical exercise by increasing glycosaminoglycan content, as indicated by higher T1 relaxation times on dGEMRIC.
Tiderius et al. (2004) conducted a cross-sectional in healthy volunteers (n=37). Physical exercise vs. Nonexercising individuals was evaluated on T1-relaxation time (mean of medial and lateral femoral cartilage) (p=0.0004 (Group 1 vs 2); 0.0002 (Group 2 vs 3)). Higher levels of physical exercise were associated with significantly longer T1-relaxation times in knee cartilage (382 ms in nonexercisers vs 424 ms in moderate exercisers vs 476 ms in elite runners).
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