What question did this study set out to answer?

To investigate the spatially localized relationship between glycosaminoglycan (GAG) concentration measured by dGEMRIC and native tissue stiffness across intact human tibial plateaus.

July 21, 2004Journal of Orthopaedic Research®

Spatially‐localized correlation of dGEMRIC‐measured GAG distribution and mechanical stiffness in the human tibial plateau

View Full Paper

Ask AI

Bookmark

Authors

JSJoseph T. SamoskyUniversity of Pittsburgh DBDeborah BursteinBeth Israel Deaconess Medical Center WGW. Eric L. GrimsonVassar College

Discussion

Member takes

Implication

Biomechanical study demonstrates strong correlations between dGEMRIC-measured GAG concentration and localized stiffness in human tibial plateaus, suggesting MRI can map cartilage mechanical health.

Key Points

To investigate the spatially localized relationship between glycosaminoglycan (GAG) concentration measured by dGEMRIC and native tissue stiffness across intact human tibial plateaus.
Three intact tibial plateaus harvested from patients undergoing total knee arthroplasty were examined using delayed gadolinium-enhanced MRI of cartilage (dGEMRIC).
Cartilage stiffness was evaluated across 33 to 44 locations per plateau using non-destructive focal indentation testing to record load responses.
The dGEMRIC index (T1Gd) was correlated with mechanical indentation stiffness across varying tissue depths and anatomical regions (central versus peripheral submeniscal areas).
Local dGEMRIC index values correlated strongly with tissue stiffness when GAG was averaged over an indentation-matched depth (Pearson r = 0.90, 0.64, and 0.81; p < 0.0001).
Correlation coefficients decreased when GAG concentrations were averaged over deeper cartilage zones rather than the localized depth of indentation.
Separating central and peripheral submeniscal regions improved correlation strength, indicating that non-GAG factors also contribute to regional cartilage stiffness.

Cite This Study

Samosky et al. (2004) studied this question.

synapsesocial.com/papers/6a898757d89205768aeb32d7 https://doi.org/10.1016/j.orthres.2004.05.008

View Full Paper

Ask AI

Bookmark

Implication

Biomechanical study demonstrates strong correlations between dGEMRIC-measured GAG concentration and localized stiffness in human tibial plateaus, suggesting MRI can map cartilage mechanical health.

Spatially‐localized correlation of dGEMRIC‐measured GAG distribution and mechanical stiffness in the human tibial plateau

Discussion

Member takes

Implication

Key Points

Cite This Study

Spatially‐localized correlation of dGEMRIC‐measured GAG distribution and mechanical stiffness in the human tibial plateau

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider