Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 29, 2017Cold Spring Harbor Perspectives in BiologyOpen Access

Hold Me, but Not Too Tight—Endothelial Cell–Cell Junctions in Angiogenesis

View Full Paper
Ask AI
Bookmark
Share

Authors

ASAnna SzymborskaHGHolger Gerhardt

Discussion

Loading...

Member takes

Overview

Literature review reveals dynamic regulation of endothelial cell junctions during vascular development, indicating how balancing barrier integrity and motility coordinates vessel formation.

Key Points

  • To review recent molecular insights into how endothelial cell–cell junctions balance structural barrier integrity with dynamic cellular rearrangements during blood vessel development.
  • Narrative review synthesizing molecular and cellular mechanisms regulating endothelial cell–cell adhesion.
  • Evaluation of junctional dynamics across stages of vascular remodeling, including sprouting, anastomosis, and lumen formation.
  • Endothelial cell junctions dynamically resolve opposing physiological requirements by preserving barrier tightness against leaks while granting cellular plasticity.
  • Coordinated adhesion signaling orchestrates cell rearrangement, sprout elongation, and lumen stabilization during functional vascular network remodeling.

Cite This Study

Szymborska et al. (2017) studied this question.

synapsesocial.com/papers/6a6cc2d731a3df824326cc88https://doi.org/10.1101/cshperspect.a029223
View Full Paper
Ask AI
Bookmark
Share