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Literature review reveals dynamic regulation of endothelial cell junctions during vascular development, indicating how balancing barrier integrity and motility coordinates vessel formation.
Endothelial cell-cell junctions must perform seemingly incompatible tasks during vascular development-providing stable connections that prevent leakage, while allowing dynamic cellular rearrangements during sprouting, anastomosis, lumen formation, and functional remodeling of the vascular network. This review aims to highlight recent insights into the molecular mechanisms governing endothelial cell-cell adhesion in the context of vascular development.
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Szymborska et al. (2017) studied this question.
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