Key result
Refeeding previously underfed ewes and cows sharply increased adipose tissue lipoprotein lipase activity by 19-25-fold and fatty acid synthase activity by 6-8-fold, along with their mRNA levels.
Population
Adult non-lactating non-pregnant Holstein cows and Lacaune ewes
Comparison
Refeeding for 21 days and 10 days after a… vs Restricted diet for 10 days or 8 days
Design
Preclinical
Follow-up
10 to 21 days of refeeding
Authors
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May not yet inform human lipid strategies; extends ruminant gene regulation models but leaves open translational relevance.
Effect estimate: 19-25-fold increase
p-value: p=<0.001
Nutritional factors strongly regulate the expression of LPL and FAS genes by pretranslational mechanisms in ruminant adipose tissue, but have less clear effects on the HSL gene.
Bonnet et al. (1998) studied Nutritional regulation of adipose tissue enzymes (n=8). Refeeding vs. Underfeeding (20% of maintenance energy requirement) was evaluated on Lipoprotein lipase (LPL) activity in adipose tissue (19-25-fold increase, p=<0.001). Refeeding previously underfed ewes and cows sharply increased adipose tissue lipoprotein lipase activity by 19-25-fold and fatty acid synthase activity by 6-8-fold, along with their mRNA levels.
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