Key result
Muscles with oxidative, type I fibers expressed higher levels of LPL mRNA than glycolytic, type II fibers, with LPL activity in heart and soleus increasing 3- to 4-fold in hypothyroid rats.
Population
Rats (fed, fasted, and hypothyroid)
Comparison
Feeding and hypothyroidism vs Fasted state and euthyroid state
Design
Preclinical
Authors
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Predominant EXT LPL fraction with similar HR activity in rat oxidative muscles; hypothesis-generating for human fiber-type regulation.
p-value: p=<0.05
This preclinical study demonstrates that lipoprotein lipase expression is differentially regulated by feeding and thyroid status depending on muscle fiber type.
Ong et al. (1994) studied Lipid metabolism. Feeding and hypothyroidism vs. Fasting and euthyroid state was evaluated on Lipoprotein lipase (LPL) activity, mass, and mRNA levels (p=<0.05). Muscles with oxidative, type I fibers expressed higher levels of LPL mRNA than glycolytic, type II fibers, with LPL activity in heart and soleus increasing 3- to 4-fold in hypothyroid rats.
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