What question did this study set out to answer?

To determine the molecular mechanism responsible for increased lipoprotein lipase (LPL) translation during hypothyroidism.

November 1, 1996Journal of Lipid ResearchOpen Access

Translational regulation of lipoprotein lipase by thyroid hormone is via a cytoplasmic repressor that interacts with the 3' untranslated region

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Authors

PKPhilip A. KernUniversity of Kentucky GRGouri RanganathanCentral Arkansas Veterans Healthcare System AYAda YukhtCedars-Sinai Medical Center

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Implication

Experimental study reveals that hypothyroidism increases lipoprotein lipase translation via reduced cytoplasmic repressor activity in rat adipocytes, suggesting a mechanism for catecholamine...

Key Points

To determine the molecular mechanism responsible for increased lipoprotein lipase (LPL) translation during hypothyroidism.
Isolated adipocytes and heart tissue fractions from control and hypothyroid rats to measure LPL and hormone-sensitive lipase synthesis.
Assayed translation in cell-free in vitro translation systems using human LPL mRNA variants, truncation constructs, and competing sense RNA strands.
Control adipocyte extracts contained a translation-inhibitory factor whose repressor activity was 8-fold lower in hypothyroid extracts.
Translational repression mapped specifically to nucleotides 1599–1638 within the proximal 3' untranslated region of the LPL mRNA.

Cite This Study

Kern et al. (1996) studied this question.

synapsesocial.com/papers/6a836fdc4d9429eb2816767d https://doi.org/10.1016/s0022-2275(20)37482-4

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Implication

Experimental study reveals that hypothyroidism increases lipoprotein lipase translation via reduced cytoplasmic repressor activity in rat adipocytes, suggesting a mechanism for catecholamine...

Translational regulation of lipoprotein lipase by thyroid hormone is via a cytoplasmic repressor that interacts with the 3' untranslated region

Discussion

Member takes

Implication

Key Points

Cite This Study

Translational regulation of lipoprotein lipase by thyroid hormone is via a cytoplasmic repressor that interacts with the 3' untranslated region

Discussion

Member takes

Implication

Key Points

Cite This Study

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