Key result
Lipoprotein lipase mRNA was localized to cardiac myocytes and adipocytes but not interstitial cells, indicating LPL is produced primarily by cardiac myocytes in human myocardium.
Population
Formalin-fixed myocardial samples from 25 cardiomyopathy patients and 7 control patients (n=32)
Design
Other
Authors
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Provides human LPL localization data for metabolic models; leaves open its role in cardiomyopathy.
Cross-Sectional (n=32)
Lipoprotein lipase in the human myocardium is primarily synthesized by cardiac myocytes rather than interstitial cells, and is subsequently translocated to sites of utilization.
O’Brien et al. (1994) conducted a cross-sectional in Cardiomyopathy (n=32). Lipoprotein lipase (LPL) localization was evaluated on Location and source of LPL protein and mRNA in human myocardium. Lipoprotein lipase mRNA was localized to cardiac myocytes and adipocytes but not interstitial cells, indicating LPL is produced primarily by cardiac myocytes in human myocardium.
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