December 1, 1991Journal of Lipid ResearchOpen Access

Lipoprotein lipase in lungs, spleen, and liver: synthesis and distribution.

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Population

Adult guinea pigs (lung, spleen, and liver tissues)

Design

Preclinical

Authors

LCL. CampsRadboud University Nijmegen MRManuel ReinaUniversitat de Barcelona MLMiquel LloberaUniversitat de Barcelona

Discussion

Member takes

Implication

Questions endothelial LPL synthesis in metabolic organs; leaves open human relevance for lipid disorders.

Structured PICO

Population

Adult guinea pigs (lung, spleen, and liver tissues)

Intervention

In situ hybridization (using a RNA probe) and immunocytochemistry

Outcome

Specific cell expression of the LPL gene and corresponding protein distributionsurrogate

This study demonstrates that in tissues with lower LPL activity, the enzyme is synthesized by macrophages and Kupffer cells rather than endothelial cells, providing insight into lipid metabolism pathways.

Cite This Study

Camps et al. (1991) studied this question.

synapsesocial.com/papers/6a928cf99da65ccb784a052a https://doi.org/10.1016/s0022-2275(20)41891-7

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Lipoprotein lipase in lungs, spleen, and liver: synthesis and distribution.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lipoprotein lipase in lungs, spleen, and liver: synthesis and distribution.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider