Population
Newborn rats (and adult rats for comparison)
Comparison
[35S]methionine injection and liver perfusion… vs Adult rats (for liver synthesis comparison)
Design
Preclinical
Authors
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No immediate implications for neonatal lipoprotein management; leaves open developmental regulation of hepatic LPL synthesis in humans.
Newborn rat livers actively synthesize lipoprotein lipase, which localizes to vessel walls and is accessible to the bloodstream for lipoprotein metabolism.
Vilaró et al. (1988) studied this question.
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