Key result
Sulfhydryl reducing agents augmented, whereas oxidizing agents inhibited, maxi-K channel activity in tracheal myocytes by altering channel gating.
Population
Excised patches from tracheal myocytes
Comparison
Sulfhydryl redox agents applied to the cytosolic… vs Extracellular surface application or baseline…
Design
Preclinical
Authors
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Sulfhydryl redox agents modulate maxi-K gating in airway myocytes; leaves open whether this alters smooth muscle tone in vivo.
Redox modulation of cysteine thiol groups alters maxi-K channel gating in tracheal myocytes, suggesting physiological relevance of redox state on channel activity.
Wang et al. (1997) studied this question. Sulfhydryl redox agents was evaluated on Channel activity (gating of maxi-K channels). Sulfhydryl reducing agents augmented, whereas oxidizing agents inhibited, maxi-K channel activity in tracheal myocytes by altering channel gating.
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