Population
Human brain Ca2+-activated K+ channels expressed in human embryonic kidney 293 cells and Xenopus oocytes
Comparison
Intracellular application of reducing agent… vs Control conditions; KCa channels cloned from…
Design
Preclinical
Authors
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Redox modulation of hslo channels may alter neuronal excitability in oxidative stress; leaves open in vivo and clinical relevance.
Human brain Ca2+-activated K+ channels (hslo) are modulated by changes in cellular redox potential, with reducing agents enhancing and oxidizing agents decreasing channel activity.
DiChiara et al. (1997) studied this question.
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