Why the study?
Do MR phase contrast flow velocity measurements correlate with stenosis severity in patients with arteriosclerotic disease?
Observational (n=36)
Do MR phase contrast flow velocity measurements correlate with stenosis severity in patients with arteriosclerotic disease?
MR phase contrast flow velocity measurements can detect flattening of flow velocity patterns that correlate with the severity of peripheral arteriosclerotic disease.
Feasibility shown for phase-contrast flow measurements in atherosclerotic arteries; leaves open clinical utility and accuracy in larger cohorts.
Phase contrast flow velocity measurements were performed in six healthy volunteers and 30 patients with arteriosclerotic disease. The iliac arteries were investigated in 8 cases and the femoral arteries in 28 cases. In the first 24 patients, 16 evenly distributed data sets were acquired during one cardiac cycle. In the last 12 patients, a trigger pulse followed by the acquisition of 30 evenly distributed data sets was applied every second heart beat. This procedure allowed data to be acquired over a full heart cycle without any acquisition gap. The measured flow velocities were displayed as function of time. Systolic acceleration, postsystolic deceleration and pulsatility of flow velocity were calculated and compared with stenosis grades determined from DSA angiograms. Flattening of the flow velocity patterns was found to correlate with the local severity of arteriosclerotic disease.
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Krug et al. (1995) conducted an observational in Arteriosclerotic disease (n=36). Phase contrast flow velocity measurements vs. DSA angiograms was evaluated on Correlation of flow velocity patterns with stenosis grades determined from DSA angiograms.
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