What is the clinical evidence from this study?

Study design: Cohort. Population: Chronic coronary syndrome (n=1353). Intervention: Elevated triglyceride-glucose (TyG) index vs. Lowest TyG index tertile. Primary outcome: First occurrence of total major adverse cardiovascular events (MACEs) within one year (HR 2.297, 95% CI 1.842-2.864, p=<0.001).

November 28, 2023Cardiovascular DiabetologyOpen Access

Prognostic value of triglyceride-glucose index in patients with chronic coronary syndrome undergoing percutaneous coronary intervention

Q: What are the key findings of this study?

An elevated triglyceride-glucose index (highest tertile) was associated with a significantly increased risk of major adverse cardiovascular events (HR 2.297) compared to the lowest tertile in patients with chronic coronary syndrome undergoing percutaneous coronary intervention.

View Full Paper

Ask AI

Bookmark

Key result

An elevated triglyceride-glucose index (highest tertile) was associated with a significantly increased risk of major adverse cardiovascular events (HR 2.297) compared to the lowest tertile in patients with chronic coronary syndrome undergoing percutaneous coronary intervention.

Why the study?

The role of the triglyceride-glucose index in chronic coronary syndrome progression has not been extensively assessed, especially following revascularization.

Does an elevated TyG index predict MACEs in patients with chronic coronary syndrome undergoing PCI?

Population

1353 CCS patients undergoing PCI

Comparison

Groups divided according to TyG index tertiles

Design

Retrospective database cohort study

Follow-up

1-year

Authors

STShiyi TaoBeijing University of Chinese Medicine LYLintong YuXiyuan Hospital JLJun LiAnhui University of Traditional Chinese Medicine

Discussion

Member takes

Overview

May support TyG index for risk stratification in CCS-PCI; leaves open prospective validation before clinical use.

Study Design

Type

Cohort (n=1,353)

Multicenter

Structured PICO

Does an elevated TyG index predict MACEs in patients with chronic coronary syndrome undergoing PCI?

Population

1,353 adult patients (aged 18-80) with chronic coronary syndrome undergoing percutaneous coronary intervention with drug-eluting stents, followed for 1 year.

Exposure

Elevated Triglyceride-glucose (TyG) index (highest tertile ≥ 9.06)

Comparator

Lowest TyG index tertile (< 8.59)

Outcome

Composite of total MACEs (unplanned revascularization, in-stent restenosis, non-fatal myocardial infarction, or other cardiovascular events including cardiac death, stroke, unplanned rehospitalization for cardiac causes) within 1-year follow-upcomposite

Main Result

Hazard Ratio: 2.297 (95% CI 1.842–2.864)

Absolute Event Rate: 57.99% vs 29.45%

p-value: p=<0.001

Limitations

Single-center, retrospective study based on Chinese patients, which may introduce selection bias and limit generalizability.
Only baseline measurements at admission were available, lacking data at different time points during the follow-up period.
Potential for residual confounding factors despite adjustments for known covariates.
Limited clinical information collected to compare the TyG index with other predictors for prognosis.

Cite This Study

Tao et al. (2023) conducted a cohort in Chronic coronary syndrome (n=1,353). Elevated triglyceride-glucose (TyG) index vs. Lowest TyG index tertile was evaluated on First occurrence of total major adverse cardiovascular events (MACEs) within one year (HR 2.297, 95% CI 1.842-2.864, p=<0.001). An elevated triglyceride-glucose index (highest tertile) was associated with a significantly increased risk of major adverse cardiovascular events (HR 2.297) compared to the lowest tertile in patients with chronic coronary syndrome undergoing percutaneous coronary intervention.

synapsesocial.com/papers/6a6ccfe65d37378ac1db5b4f https://doi.org/10.1186/s12933-023-02060-7

View Full Paper

Ask AI

Bookmark

November 28, 2023Cardiovascular DiabetologyOpen Access

Prognostic value of triglyceride-glucose index in patients with chronic coronary syndrome undergoing percutaneous coronary intervention

View Full Paper

Ask AI

Bookmark

Key result

Why the study?

The role of the triglyceride-glucose index in chronic coronary syndrome progression has not been extensively assessed, especially following revascularization.

Does an elevated TyG index predict MACEs in patients with chronic coronary syndrome undergoing PCI?

Population

1353 CCS patients undergoing PCI

Comparison

Groups divided according to TyG index tertiles

Design

Retrospective database cohort study

Follow-up

1-year

Authors

STShiyi TaoBeijing University of Chinese Medicine LYLintong YuXiyuan Hospital JLJun LiAnhui University of Traditional Chinese Medicine

Discussion

Member takes

Overview

May support TyG index for risk stratification in CCS-PCI; leaves open prospective validation before clinical use.

Study Design

Type

Cohort (n=1,353)

Multicenter

Structured PICO

Does an elevated TyG index predict MACEs in patients with chronic coronary syndrome undergoing PCI?

Population

1,353 adult patients (aged 18-80) with chronic coronary syndrome undergoing percutaneous coronary intervention with drug-eluting stents, followed for 1 year.

Exposure

Elevated Triglyceride-glucose (TyG) index (highest tertile ≥ 9.06)

Comparator

Lowest TyG index tertile (< 8.59)

Outcome

Main Result

Hazard Ratio: 2.297 (95% CI 1.842–2.864)

Absolute Event Rate: 57.99% vs 29.45%

p-value: p=<0.001

Limitations

Single-center, retrospective study based on Chinese patients, which may introduce selection bias and limit generalizability.
Only baseline measurements at admission were available, lacking data at different time points during the follow-up period.
Potential for residual confounding factors despite adjustments for known covariates.
Limited clinical information collected to compare the TyG index with other predictors for prognosis.

Cite This Study

synapsesocial.com/papers/6a6ccfe65d37378ac1db5b4f https://doi.org/10.1186/s12933-023-02060-7

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark