Key result
Autoimmunity to cardiac antigens is linked to long-COVID cardiac dysfunction.
Observational
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Reveals that long COVID-19 cardiac complications stem from autoimmunity against cardiac self-antigens, indicating an immune-mediated mechanism for post-viral heart dysfunction.
oronavirus disease 2019 (COVID-19) led to extensive morbidity and mortality. Attention is shifting to long-term effects persisting after acute infection, termed long/post-COVID-19, including cardiac sequelae. 1 Cardiovascular magnetic resonance (CMR) abnormality is present at 6-month follow-up in half of patients recovered from COVID-19 with in-hospital high-sensitivity troponin elevation. 2 Lack of preinfection data renders it hard to exclude causality from pre-existing conditions, rather than infection sequelae. Yet larger studies show increased risk of incident cardiovascular disease in the year after COVID-19,
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Cremonesi et al. (2023) conducted an observational in Long COVID-19 cardiac complications. Autoimmunity to cardiac self-antigens was evaluated. Autoimmunity to cardiac self-antigens is associated with long COVID-19 cardiac complications sufficient to cause cardiac dysfunction.
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