Key result
In healthy adults, the pooled mean of native T1 was 976 msec at 1.5 T and 1159 msec at 3.0 T, and the pooled mean of extracellular volume was 25.9% at both field strengths, though significant heterogeneity was observed.
Meta-Analysis (n=5,541)
Native T1 and ECV measurements in healthy adults show significant heterogeneity based on MRI field strength, vendor, and pulse sequence, highlighting the need for institution-specific reference ranges.
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Substantial heterogeneity in native T1 and ECV warrants caution in cross-study comparisons; extends calls for protocol standardization in CMR research.
Gottbrecht et al. (2018) conducted a meta-analysis in Healthy adults (n=5,541). Cardiac MRI T1 and ECV mapping was evaluated on Pooled mean of native T1 at 1.5 T (95% CI 969-983). In healthy adults, the pooled mean of native T1 was 976 msec at 1.5 T and 1159 msec at 3.0 T, and the pooled mean of extracellular volume was 25.9% at both field strengths, though significant heterogeneity was observed.
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