Key result
South Asians with type 2 diabetes had a higher adjusted risk of developing microalbuminuria (HR 1.4; 95% CI 1.2-1.6) and macroalbuminuria (HR 1.2; 95% CI 1.0-1.4) compared to Western Europeans.
Why the study?
Data on differences in the development and progression of diabetic nephropathy between ethnic groups are not consistent, despite South Asians having an increased risk of developing diabetes.
Does South Asian ethnicity increase the risk of developing and progressing albuminuria in patients with type 2 diabetes compared to Western European ethnicity?
Population
1269 South Asians and 2272 Dutch adults with type 2 diabetes
Comparison
South Asians vs Western Europeans
Design
Closed cohort study
Authors
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May support intensified albuminuria surveillance in South Asians with type 2 diabetes; leaves open whether ethnicity-specific strategies improve outcomes.
Cohort (n=3,541)
No
Does South Asian ethnicity increase the risk of developing and progressing albuminuria in patients with type 2 diabetes compared to Western European ethnicity?
Hazard Ratio: 1.4 (95% CI 1.2–1.6)
South Asians with type 2 diabetes have a higher risk of developing micro- and macroalbuminuria compared to Western Europeans, though progression rates once microalbuminuria is established are similar.
Niel et al. (2024) conducted a cohort in Type 2 diabetes (n=3,541). South Asian ethnicity vs. Western European ethnicity was evaluated on Development of microalbuminuria (HR 1.4, 95% CI 1.2-1.6). South Asians with type 2 diabetes had a higher adjusted risk of developing microalbuminuria (HR 1.4; 95% CI 1.2-1.6) and macroalbuminuria (HR 1.2; 95% CI 1.0-1.4) compared to Western Europeans.
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