Answers are grounded in this paper and cite their sources.
Palladium-catalyzed methylene β-C(sp 3 )–H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp 3 )–H bond activation.
No takes yet. Share an insight, caveat, or question.
Hong et al. (2017) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: