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Hip to be square: A strategy for assembling tetrasubstituted cyclobutanes is reported in the context of a short, protecting-group-free synthesis of the proposed structure of pipercyclobutanamide A. The route features sequential CH functionalizations on an unactivated cyclobutane wherein CC bonds to aryl and styryl groups are made one by one in a stereocontrolled fashion. DG=directing group.
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Gutekunst et al. (2012) studied this question.
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