Key result
The NITRITE-AMI trial is a study protocol designed to evaluate whether a bolus of intracoronary sodium nitrite reduces infarct size in 80 patients with ST-elevation myocardial infarction.
Why the study?
Does intracoronary sodium nitrite reduce infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention?
Population
80 patients presenting with ST-elevation myocardial infarction undergoing primary percutaneous coronary…
Comparison
Bolus of intracoronary sodium nitrite at the… vs Placebo (sodium chloride) at the time of PPCI
Design
Other, Randomised, Double-blind, placebo-controlled
Follow-up
48 hours (primary outcome), 1 year (secondary outcomes)
Authors
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Reperfusion injury persists without therapy in AMI; leaves open need for targeted cardioprotective strategies in PPCI.
RCT (n=80)
double-blind
randomised
No
Does intracoronary sodium nitrite reduce infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention?
This study protocol describes a randomized controlled trial to evaluate whether intracoronary sodium nitrite reduces reperfusion injury and infarct size in patients undergoing primary PCI for STEMI.
Jones et al. (2013) conducted an RCT in ST-elevation myocardial infarction (n=80). intracoronary sodium nitrite vs. placebo (sodium chloride) was evaluated on infarct size assessed by creatine kinase area under the curve (AUC) over 48 h. The NITRITE-AMI trial is a study protocol designed to evaluate whether a bolus of intracoronary sodium nitrite reduces infarct size in 80 patients with ST-elevation myocardial infarction.
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