Why the study?
Despite prompt revascularization of acute myocardial infarction, substantial myocardial injury from ischaemia reperfusion injury remains, and therapies to reduce this injury are of interest.
Does intravenous sodium nitrite administered immediately prior to reperfusion reduce myocardial infarct size in patients with acute STEMI?
Population
229 patients with acute STEMI undergoing PPCI
Comparison
Intravenous sodium nitrite infusion vs matching placebo infusion immediately before PPCI
Design
Double-blind randomized placebo-controlled parallel-group trial
Follow-up
6 months
Authors
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Nitrite before reperfusion does not reduce infarct size in STEMI; challenges experimental promise and closes this therapeutic avenue.
Does intravenous sodium nitrite administered immediately prior to reperfusion reduce myocardial infarct size in patients with acute STEMI?
Intravenous sodium nitrite administered immediately prior to reperfusion in patients with acute STEMI does not reduce myocardial infarct size.
Siddiqi et al. (2014) studied this question.
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