Key result
Combined benazepril-amlodipine significantly increased cardiac interstitial fluid NOX and cGMP and reduced TNF-alpha compared to either drug alone in rats with induced myocardial ischemia (P<0.001).
Why the study?
Does combined benazepril-amlodipine improve inflammatory and vasodilatory mediators in rats with induced myocardial ischemia?
Does combined benazepril-amlodipine improve inflammatory and vasodilatory mediators in rats with induced myocardial ischemia?
p-value: p=<0.001
Combination therapy with benazepril and amlodipine synergistically improves local cardiac nitric oxide and cGMP levels while reducing TNF-alpha in a rat model of myocardial ischemia.
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Rat ischemia model findings are hypothesis-generating; leaves open whether ACEIs, CCBs, or diuretics reduce cardiac inflammation mediators in patients.
Siragy et al. (2006) studied Induced myocardial ischemia. Combined benazepril-amlodipine vs. Untreated ischemia, sham, or monotherapies was evaluated on Cardiac interstitial fluid levels of NOX, cGMP, Ang II, and TNF-alpha (p=<0.001). Combined benazepril-amlodipine significantly increased cardiac interstitial fluid NOX and cGMP and reduced TNF-alpha compared to either drug alone in rats with induced myocardial ischemia (P<0.001).
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