Key result
Combination therapy with ramipril and sildenafil acutely improved flow-mediated dilation at 4 hours compared with placebo (+4.8±1.3%, P<0.03) in patients with chronic heart failure.
Why the study?
Does acute administration of ramipril, sildenafil, or their combination improve flow-mediated dilation in patients with chronic heart failure?
RCT (n=64)
Double-blind
randomized
Does acute administration of ramipril, sildenafil, or their combination improve flow-mediated dilation in patients with chronic heart failure?
p-value: p=<0.03
Acute administration of ramipril and sildenafil improves endothelial function in patients with chronic heart failure, with additive effects when combined.
No takes yet. Share an insight, caveat, or question.
Acute ramipril-sildenafil combination improves endothelial function in chronic heart failure; extends single-agent data and supports outcome trials.
Hryniewicz et al. (2005) conducted an RCT in chronic heart failure (n=64). Ramipril, sildenafil, or combination vs. Placebo was evaluated on Flow-mediated dilation (FMD) of the brachial artery (p=<0.03). Combination therapy with ramipril and sildenafil acutely improved flow-mediated dilation at 4 hours compared with placebo (+4.8±1.3%, P<0.03) in patients with chronic heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: