Key result
Two distinct populations of pacemaker cells (A and B cells) with different electrophysiological properties and sensitivities to TTX and Cs are present in the rabbit sinoatrial node.
Population
Rabbit sinoatrial node (SA node) tissue
Design
Preclinical
Authors
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Highlights SA node cellular heterogeneity in rabbits; leaves open functional implications for human pacemaker activity.
Demonstrates that the rabbit SA node contains two distinct pacemaker cell populations (A and B cells) driven by different ionic mechanisms.
D Kreitner (1985) studied this question. Tetrodotoxin (TTX) and Caesium ions (Cs) was evaluated on Action potential characteristics and diastolic depolarization. Two distinct populations of pacemaker cells (A and B cells) with different electrophysiological properties and sensitivities to TTX and Cs are present in the rabbit sinoatrial node.
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