September 1, 1977Circulation ResearchOpen Access

Characteristics of extracellular potentials recorded from the sinoatrial pacemaker of the rabbit.

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Population

Isolated rabbit atrium (sinoatrial pacemaker)

Design

Preclinical

Authors

MCMonica CramerMidlands Technical College MSMichael S. SiegalColumbia University JBJ. Thomas BiggerAllegheny College

Discussion

Member takes

Implication

No immediate clinical implications for arrhythmia care; leaves open translation of extracellular SA node mapping to humans.

Structured PICO

Population

Isolated rabbit atrium (sinoatrial pacemaker)

Intervention

Unipolar electrogram recording using Ag-AgCl electrodes and DC amplification, with experimental manipulations including tetrodotoxin (2-10 mg/liter) and cooling (36.5°C to 30°C)

Outcome

Extracellular potential changes associated with electrical activity of the sinoatrial pacemakersurrogate

This study demonstrates that rabbit sinoatrial pacemaker cells produce detectable and characteristic extracellular potential changes, providing a basis for identifying SA pacemaker electrical activity.

Cite This Study

Cramer et al. (1977) studied this question.

synapsesocial.com/papers/6a8654305dc285e07e73a3cb https://doi.org/10.1161/01.res.41.3.292

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Characteristics of extracellular potentials recorded from the sinoatrial pacemaker of the rabbit.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characteristics of extracellular potentials recorded from the sinoatrial pacemaker of the rabbit.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider