Key result
Targeting microcirculation offers a novel therapeutic approach to address imperfect BP control and end-organ damage.
Why the study?
Most hypertensive subjects show imperfect blood pressure control and end-organ damage improvements do not always correlate with blood pressure reduction, highlighting a need for new therapeutic perspectives such as the microcirculation.
Suggests that focusing on the microcirculation may provide new therapeutic perspectives for improving hypertension management and reducing end-organ damage.
Targeting microcirculation may offer additive benefit beyond BP lowering in hypertension; leaves open whether this improves hard outcomes.
T he number of effective agents available for the treatment of hypertension is now substantial. However, in spite of this, most would agree that there is still considerable scope for improvement in the way hypertension is managed. In many countries, the great majority of hypertensive subjects still show imperfect blood pressure control. 1 Furthermore, the reductions or improvements in end-organ damage seen during antihypertensive therapy do not always correlate well with the reduction in arterial blood pressure achieved. Thus, there seems to be a need for new therapeutic perspectives in the treatment of hypertension. One important new perspective might be provided by an enhanced appreciation of the importance of the microcirculation in the pathophysiology and treatment of hypertension.
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Lévy et al. (2001) conducted a review in Hypertension. Targeting the microcirculation may provide important new therapeutic perspectives for the management of hypertension, addressing imperfect blood pressure control and end-organ damage.
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