Key result
The novel CCCC-SCD-Score, incorporating clinical, electrocardiographic, and echocardiographic factors, effectively predicted the risk of sudden cardiac death with a C-index of 0.888.
Why the study?
Most risk factors and prediction models for sudden cardiac death were developed without considering Asian populations.
Cohort (n=2,105)
No
A novel point-based scoring system incorporating clinical, ECG, and echocardiographic data effectively predicts the risk of sudden cardiac death in an Asian general population without prior CAD or severe LV dysfunction.
BACKGROUND: Most of the factors and prediction models of sudden cardiac death (SCD) have been developed without considering the Asia population. The purpose of this study is to construct a point-based prediction model for the general population in Asia. METHODS AND RESULTS: Chin-Shan Community Cardiovascular Cohort (CCCC) is a community-based longitudinal cohort initiated between 1990 and 1991, enrolling participants aged ≥35 years and following them up until 2005. Participants with coronary artery disease (CAD) or a left ventricular ejection fraction (LVEF) of 35% were excluded from this study. The Framingham risk score function was used to derive a simple point-based prediction model. Based on bootstrapping, a novel model (CCCC-SCD-Score) was validated. A total of 2,105 participants were analyzed. The incidence rate of SCD was 0.406 per 1,000 person-years. The CCCC-SCD-Score score was calculated using age groups (maximal points=4), left ventricular hypertrophy, hypertension, left ventricular ejection fraction <40%, aortic flow rate >190 cm/s, and carotid plaque scores ≥5 (point=1 for each risk factor). The C-index of the CCCC-SCD-Score in predicting SCD risks was 0.888 (95% confidence interval: 0.807-0.969). CONCLUSIONS: For the general Asian population without a history of CAD or a LVEF <35% and who are aged >35 years, the novel model-based scoring system effectively identifies the risk for SCD using the clinical factors, electrocardiographic and echocardiographic data.
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Chen et al. (2022) conducted a cohort in Sudden cardiac death (n=2,105). CCCC-SCD-Score vs. ARIC-Framingham score and ECG risk score was evaluated on Predicting sudden cardiac death (SCD) risks (C-index) (C-index 0.888, 95% CI 0.807-0.969). The novel CCCC-SCD-Score, incorporating clinical, electrocardiographic, and echocardiographic factors, effectively predicted the risk of sudden cardiac death with a C-index of 0.888.
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