Key result
Positive end-expiratory pressure adversely affected right ventricular performance in an experimental dog model when right coronary blood flow was limited by occlusion.
Why the study?
Does positive end-expiratory pressure affect right ventricular performance and myocardial blood flow in the setting of right coronary artery occlusion in dogs?
Population
16 dogs (experimental model)
Comparison
Positive end-expiratory pressure at 20 cm H2O… vs Baseline and intact RCA flow with PEEP
Design
Preclinical
Authors
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PEEP effects on RV performance post-RCA occlusion require clinical caution; leaves open translation from this canine model to humans.
Does positive end-expiratory pressure affect right ventricular performance and myocardial blood flow in the setting of right coronary artery occlusion in dogs?
In a canine model, right ventricular performance is adversely affected by positive end-expiratory pressure when right coronary blood flow is limited.
Schulman et al. (1990) studied this question. Positive end-expiratory pressure (PEEP) vs. Baseline was evaluated on Right ventricular performance (including ejection fraction) and myocardial blood flow. Positive end-expiratory pressure adversely affected right ventricular performance in an experimental dog model when right coronary blood flow was limited by occlusion.
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