Key result
In the mouse sino-atrial node, RYR2 mRNA is expressed widely throughout the heart, whereas RYR3 mRNA expression is localized specifically to the SA-node and right atrium.
Population
Mouse sino-atrial node
Design
Preclinical
Authors
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RYR2 may contribute to SA-node Ca2+ release; leaves open functional validation in pacemaking.
The study demonstrates that both RYR2 and RYR3 isoforms are expressed in the mouse sino-atrial node, suggesting both may participate in pacemaker activity.
Masumiya et al. (2003) studied this question. In the mouse sino-atrial node, RYR2 mRNA is expressed widely throughout the heart, whereas RYR3 mRNA expression is localized specifically to the SA-node and right atrium.
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