Why the study?
Does ryanodine-induced blockade of sarcoplasmic reticulum Ca2+ release abolish pacemaking in the intact rabbit sinoatrial node?
Population
Intact sinoatrial node and isolated sinoatrial node cells from rabbits
Comparison
Ryanodine 30 micromol/L vs Baseline spontaneous activity
Design
Preclinical
Authors
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Sarcoplasmic reticulum Ca2+ release does not play a dominating role in pacemaking in the rabbit sinoatrial node, challenging previous hypotheses based on isolated cell models.
Does ryanodine-induced blockade of sarcoplasmic reticulum Ca2+ release abolish pacemaking in the intact rabbit sinoatrial node?
Sarcoplasmic reticulum Ca2+ release does not play a dominating role in pacemaking in the rabbit sinoatrial node, challenging previous hypotheses based on isolated cell models.
Honjo et al. (2003) studied this question.
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