Population
Mammalian (rabbit) and amphibian sinoatrial node models
Design
Preclinical
Authors
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Ca2+ transient effects on pacemaker rate warrant no clinical change yet; leaves open targeted sinoatrial node therapies pending validation.
Intracellular Ca2+ transients are crucial for sinoatrial node pacemaker activity, modulating multiple ionic currents to regulate the spontaneous beating rate.
Boyett et al. (2001) studied this question.
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