June 1, 1997AJP Heart and Circulatory Physiology

Regional differences in the role of the Ca2+ and Na+ currents in pacemaker activity in the sinoatrial node

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Population

Rabbit sinoatrial node

Design

Preclinical

Authors

IKI. KodamaNational Institute of Technology, Tokyo College MNM. R. NikmaramIran University of Medical Sciences MBMark R. BoyettElectrophysiology

Discussion

Member takes

Implication

Does not support clinical translation; hypothesis-generating for regional ion current roles in sinoatrial node pacemaking.

Structured PICO

Population

Rabbit sinoatrial node (isolated right atrium containing the whole node or small balls of tissue approximately 0.3-0.4 mm in diameter from center and periphery)

Intervention

2 microM nifedipine (L-type Ca2+ current block) and 20 microM tetrodotoxin (Na+ current block)

Outcome

Spontaneous action potentials (takeoff potential, upstroke velocity, and spontaneous activity rate)surrogate

In the rabbit sinoatrial node, L-type Ca2+ currents are essential for pacemaking in the center, while Na+ currents play a major role in the periphery.

Cite This Study

Kodama et al. (1997) studied this question.

synapsesocial.com/papers/6a85a6f0d06b31cc19d0d287 https://doi.org/10.1152/ajpheart.1997.272.6.h2793

View Full Paper

Ask AI

Bookmark

Regional differences in the role of the Ca2+ and Na+ currents in pacemaker activity in the sinoatrial node

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regional differences in the role of the Ca2+ and Na+ currents in pacemaker activity in the sinoatrial node

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider