October 1, 1998AJP Heart and Circulatory Physiology

Regional differences in effects of 4-aminopyridine within the sinoatrial node

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Population

Rabbit sinoatrial node tissue preparations and intact sinoatrial node

Design

Preclinical

Authors

MBMark R. BoyettElectrophysiology HHH. HonjoNagoya University MYMotoji YamamotoKyushu University

Discussion

Member takes

Implication

Regional 4-AP-sensitive currents in rabbit SAN are hypothesis-generating; does not support changes in clinical sinus node management.

Structured PICO

Population

Rabbit sinoatrial node tissue preparations (small ball-like, diameter approximately 0.3-0.4 mm) and intact sinoatrial node

Intervention

5 mM 4-aminopyridine (4-AP)

Outcome

Action potential characteristics (plateau, duration, maximum diastolic potential) and pacemaker activitysurrogate

4-aminopyridine-sensitive outward current plays a major, regionally variable role in action potential repolarization and pacemaker activity in the rabbit sinoatrial node.

Cite This Study

Boyett et al. (1998) studied this question.

synapsesocial.com/papers/6a71a781abc331a85807add2 https://doi.org/10.1152/ajpheart.1998.275.4.h1158

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Regional differences in effects of 4-aminopyridine within the sinoatrial node

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regional differences in effects of 4-aminopyridine within the sinoatrial node

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider