Minor contribution of cytosolic Ca2+transients to the pacemaker rhythm in guinea pig sinoatrial node cells

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Population

Isolated guinea pig sinoatrial node cells and mathematical pacemaker models

Comparison

Chelating intracellular Ca2+ or disrupting SR… vs Normal Ca2+ dynamics / baseline state

Design

Preclinical

Follow-up

up to >5 min

Authors

Discussion

Challenges Ca2+ clock primacy in guinea pig SAN pacemaking; leaves open relevance to other species or intact human physiology.

Population

Isolated guinea pig sinoatrial node cells and mathematical pacemaker models ('Ca2+ clock' and 'membrane clock')

Intervention

Chelating intracellular Ca2+ (with 10 mM BAPTA) or disrupting SR Ca2+ dynamics with high doses of SR blockers

Comparator

Normal Ca2+ dynamics / baseline state

Outcome

Rate of spontaneous action potential / pacemaker rhythmsurrogate

The 'Ca2+ clock' mechanism does not appear to be the primary driver of pacemaker rhythm in guinea pig sinoatrial node cells.

Himeno et al. (2010) studied this question.

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