What question did this study set out to answer?

To evaluate the clinical and demographic prognostic factors associated with mortality in patients with community-acquired pneumococcal bacteremia.

September 1, 2000The Journal of Infectious Diseases

Prospective Study of Prognostic Factors in Community‐Acquired Bacteremic Pneumococcal Disease in 5 Countries

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To evaluate the clinical and demographic prognostic factors associated with mortality in patients with community-acquired pneumococcal bacteremia.
Conducted a 2-year prospective multicenter observational study across 5 centers located in Canada, the United States, the United Kingdom, Spain, and Sweden (N = 460).
Assessed independent predictors of mortality using multivariate logistic regression analysis.
Independent risk factors for death were age >65 years (OR 2.2), nursing home residence (OR 2.8), chronic pulmonary disease (OR 2.5), mechanical ventilation (OR 4.4), and acute physiology scores (OR 7.6 for scores 9–14; OR 22 for 15–17; OR 41 for >17).
Mortality was 26% in patients with meningitis, while among pneumonia patients without meningitis, mortality was significantly higher with ≥2 lobes involved compared to 1 lobe (19% vs. 7%, P = .0016).
Case-fatality rates varied substantially across centers: 20% in the United States and Spain, 13% in the United Kingdom, 8% in Sweden, and 6% in Canada.

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Implication

Prospective study reveals clinical predictors of mortality in community-acquired pneumococcal bacteremia, highlighting the major impact of acute disease severity and comorbidities.

Cite This Study

Kalin et al. (2000) studied this question.

synapsesocial.com/papers/6a6d1a86ac440176ef26f6c2 https://doi.org/10.1086/315760

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Implication

Prospective study reveals clinical predictors of mortality in community-acquired pneumococcal bacteremia, highlighting the major impact of acute disease severity and comorbidities.

Prospective Study of Prognostic Factors in Community‐Acquired Bacteremic Pneumococcal Disease in 5 Countries

Key Points

Discussion

Implication

Cite This Study

Prospective Study of Prognostic Factors in Community‐Acquired Bacteremic Pneumococcal Disease in 5 Countries

Key Points

Discussion

Implication

Cite This Study

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