Key result
SERINC5 acts as a broad-spectrum host antiviral restriction factor that inhibits infection by diverse viruses, including HIV-1, SARS-CoV-2, influenza A virus, and hepatitis B virus.
SERINC5 is a broad-spectrum antiviral restriction factor that inhibits multiple unrelated virus families through various mechanisms including blocking virus-cell membrane fusion and modulating innate immunity.
SERINC5 may limit IAV spread; leaves open whether countermeasures exist for therapeutic targeting.
Recent studies reported that SERINC5 inhibits influenza A virus (IAV) infection as well, although, no viral protein was identified to counteract the antiviral effect of SERINC5 Furthermore, hepatitis B virus (HBV) and classical swine flu virus (CSFV) were found to be
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Timilsina et al. (2023) conducted a review in Viral infections. SERINC5 was evaluated. SERINC5 acts as a broad-spectrum host antiviral restriction factor that inhibits infection by diverse viruses, including HIV-1, SARS-CoV-2, influenza A virus, and hepatitis B virus.
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