Key result
Aging in healthy individuals was associated with increased septal and wall thickness in both sexes, increased LV diameter and mass predominantly in males, and progressive slowing of LV function.
Why the study?
How do age and sex influence left ventricular anatomy and function in normal individuals?
Cross-Sectional (n=150)
How do age and sex influence left ventricular anatomy and function in normal individuals?
Normal aging is associated with sex-specific changes in left ventricular structure and function, highlighting the need for age- and sex-specific reference values in echocardiography.
May inform sex-specific echo reference values with aging; hypothesis-generating and should not yet change practice.
Using digitized M-mode echograms, we evaluated the influence of sex on age-related changes of left ventricular (LV) anatomy and function in a normal population (75 males and 75 females, subdivided in age groups for each decade from 20 to 70 years). Aging is accompanied with an increase in septal and wall thickness in both males and females and in LV diameter only in males, with a progressive increase of LV mass more pronounced in males than in females. As regards LV function we found a progressive slowing of relaxation in females and of both contraction and relaxation in males, not related to changes in LV mass.
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Grandi et al. (2008) conducted a cross-sectional in Healthy individuals (n=150). Age and sex was evaluated on Left ventricular anatomy and function. Aging in healthy individuals was associated with increased septal and wall thickness in both sexes, increased LV diameter and mass predominantly in males, and progressive slowing of LV function.
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