Key result
Advancing age was significantly correlated with decreased left ventricular long axis maximal systolic velocity (r=0.61, p<0.0001) and maximal early diastolic filling velocity (r=0.87, p<0.0001).
Why the study?
How do age and gender affect left ventricular long axis function and geometry in healthy individuals?
Cross-Sectional (n=82)
How do age and gender affect left ventricular long axis function and geometry in healthy individuals?
Effect estimate: r=0.61 (maximal systolic velocity); r=0.87 (maximal early diastolic filling velocity)
p-value: p=<0.0001
Age-related functional changes in the left ventricle are more prominent in the long axis, while gender differences are more pronounced in short axis and volume measurements.
Supports age-adjusted long-axis velocity norms in echo reporting; leaves open prognostic relevance and gender effects in healthy aging.
AIMS: To study age and gender related alterations in left ventricular (LV) long axis function. METHODS: Eighty-two healthy individuals from the general population in three age groups were investigated. LV long axis and short axis function and dimensions were studied with echocardiographic M-mode and two-dimensional technique. RESULTS: The most prominent age related differences were observed in LV long axis function, whereas only minor alterations in short axis function were noticed. Both systolic and diastolic long axis function decreased with advancing age; maximal systolic velocity (r=0.61, p<0.0001), maximal early diastolic filling velocity (r=0.87, p<0.0001). The length of the long axis decreased with age, while the relative contraction amplitude was maintained. LV global and short axis measurements revealed significant differences between genders, males having generally larger dimensions, even when correcting for body surface area. Females exhibited a more pronounced remodelling process with advancing age. CONCLUSION: Functional age related changes in LV function are more prominent in the long axis, while differences between genders are more pronounced in short axis and in volume measurements. These findings might be of importance when remodelling processes are evaluated, as these appear to be different in men and women and also age related.
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GRUNERSVEALV et al. (2005) conducted a cross-sectional in Healthy individuals (n=82). Advancing age and gender vs. Younger age and opposite gender was evaluated on Left ventricular long axis function (maximal systolic velocity and maximal early diastolic filling velocity) (r=0.61 (maximal systolic velocity); r=0.87 (maximal early diastolic filling velocity), p=<0.0001). Advancing age was significantly correlated with decreased left ventricular long axis maximal systolic velocity (r=0.61, p<0.0001) and maximal early diastolic filling velocity (r=0.87, p<0.0001).
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