Key result
Type 1 hypokalemic and thyrotoxic periodic paralysis were associated with reduced voltage-gated Na+ and inward rectifier K+ currents, and elevated intracellular Ca2+ in intercostal muscle fibers.
Observational (n=6)
Type 1 hypokalemic and thyrotoxic periodic paralysis are associated with reduced sodium and inward rectifier potassium currents and elevated intracellular calcium in muscle fibers.
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Altered Na and Kir currents in HOPP/TPP fibers may contribute to paralysis; leaves open causal mechanisms and therapeutic implications.
Puwanant et al. (2010) conducted an observational in Type 1 hypokalemic and thyrotoxic periodic paralysis (n=6). Type 1 hypokalemic and thyrotoxic periodic paralysis vs. Controls / Euthyroid state was evaluated on Voltage-gated Na+ (I(Na)) and inward rectifier K+ (I(Kir)) currents, Na+ conductance (G(Na)), action potential thresholds, and intracellular [Ca(2+)]. Type 1 hypokalemic and thyrotoxic periodic paralysis were associated with reduced voltage-gated Na+ and inward rectifier K+ currents, and elevated intracellular Ca2+ in intercostal muscle fibers.
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