Key result
Two patients with paralytic poliomyelitis simultaneously developed neutralizing antibodies to both poliomyelitis and Coxsackie viruses after both viruses were isolated from their acute phase stools.
Case Report (n=2)
No
Patients with paralytic poliomyelitis can simultaneously develop antibodies to both poliomyelitis and Coxsackie viruses.
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May indicate dual enteroviral infection in paralytic cases; leaves open the etiologic role of Coxsackie virus.
Both poliomyelitis virus and Coxsackie virus (C virus) were isolated from the acute phase stools of several paralytic patients during an epidemic of poliomyelitis which occurred in Easton, Pa., in 1949. In 2 such cases, neutralizing antibody tests were carried out with acute and convalescent serum reacting with a suspension of virus obtained directly from acute phase stools. It was found that both patients responded to their illness by simultaneously developing antibodies both to poliomyelitis virus and to C virus.
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Melnick et al. (1950) conducted a case report in Paralytic poliomyelitis (n=2). Dual infection with poliomyelitis and Coxsackie viruses was evaluated on Development of neutralizing antibodies to both poliomyelitis virus and Coxsackie virus. Two patients with paralytic poliomyelitis simultaneously developed neutralizing antibodies to both poliomyelitis and Coxsackie viruses after both viruses were isolated from their acute phase stools.
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