Key result
ECHO 9 virus infection was associated with a 4-fold or greater rise in complement-fixing antibody titer to polioviruses in 18% of patients, suggesting shared antigens.
Observational (n=579)
ECHO 9 virus infection may cause a heterologous complement-fixing antibody response to polioviruses, suggesting shared antigens.
May confound poliovirus serology interpretation; leaves open the clinical relevance of enteroviral antigenic overlap.
Summary Sera of 579 patients with laboratory evidence of Coxsackie, ECHO, mumps, herpes simplex, WEE, SLE, or unidentified enterovirus infections were tested against unheated poliomyelitis complement-fixing (CF) antigens. Only 26 of these individuals manifested a 4-fold or greater rise in poliovirus antibody, and in four instances the antibody rises were attributable to a recent poliomyelitis vaccination or to dual infection. The titers of the heterologous antibody were generally low. It was observed that a high proportion (18%) of the patients with ECHO 9 virus infection and with no evidence of a dual infection or of vaccination against poliomyelitis, showed 4-fold or greater rises in CF antibody titer to the polioviruses. This was the only nonpoliovirus showing definite evidence of a possible sharing of common antigen(s) with the polioviruses.
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Lennette et al. (1961) conducted an observational in Nonpoliovirus viral infections (n=579). ECHO 9 virus infection vs. Other nonpoliovirus infections was evaluated on 4-fold or greater rise in poliovirus complement-fixing antibody titer. ECHO 9 virus infection was associated with a 4-fold or greater rise in complement-fixing antibody titer to polioviruses in 18% of patients, suggesting shared antigens.
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